Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, et al. Small-molecule inhibition of METT元 as a strategy against myeloid leukaemia. Yankova E, Blackaby W, Albertella M, Rak J, De Braekeleer E, Tsagkogeorga G, et al. The N(6)-methyladenosine (m(6)A)-forming enzyme METT元 controls myeloid differentiation of normal hematopoietic and leukemia cells. Vu LP, Pickering BF, Cheng Y, Zaccara S, Nguyen D, Minuesa G, et al. N(6)-Methyladenosine modulates nonsense-mediated mRNA decay in human glioblastoma. Li F, Yi Y, Miao Y, Long W, Long T, Chen S, et al. HBXIP-elevated methyltransferase METT元 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g. The m(6)A methyltransferase METT元 promotes translation in human cancer cells. Lin S, Choe J, Du P, Triboulet R, Gregory RI. METT元/YTHDF2 m(6) a axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer. Xie H, Li J, Ying Y, Yan H, Jin K, Ma X, et al. METT元-mediated m(6)A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance. Wang Q, Chen C, Ding Q, Zhao Y, Wang Z, Chen J, et al. Functions of N6-methyladenosine and its role in cancer. Therapeutic targeting of CDK7 suppresses tumor progression in intrahepatic Cholangiocarcinoma. EBioMedicine 2020 56:102821.Ĭhen HD, Huang CS, Xu QC, Li F, Huang XT, Wang JQ, et al. Stimuli-responsive prodrug-based cancer nanomedicine. Xie A, Hanif S, Ouyang J, Tang Z, Kong N, Kim NY, et al. METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST. Yang X, Zhang S, He C, Xue P, Zhang L, He Z, et al. RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2. Cell 2015 161:1388–99.Ĭhen M, Wei L, Law CT, Tsang FH, Shen J, Cheng CL, et al. N(6)-methyladenosine modulates messenger rna translation Efficiency. Wang X, Zhao BS, Roundtree IA, Lu Z, Han D, Ma H, et al. 5’ UTR m(6)A promotes cap-independent translation.
Meyer KD, Patil DP, Zhou J, Zinoviev A, Skabkin MA, Elemento O, et al. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Wang Y, Li Y, Toth JI, Petroski MD, Zhang Z, Zhao JC. N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3’-end processing. Nature 2014 505:117–20.īartosovic M, Molares HC, Gregorova P, Hrossova D, Kudla G, Vanacova S. N6-methyladenosine-dependent regulation of messenger RNA stability. Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, et al. Reading m(6)A in the Transcriptome: m(6)A-Binding Proteins.
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, et al. A METT元-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, et al. Epidemiology and molecular pathology of gallbladder cancer. Lazcano-Ponce EC, Miquel JF, Muñoz N, Herrero R, Ferrecio C, Wistuba II, et al. Misra S, Chaturvedi A, Misra NC, Sharma ID. Thus, our finding shows that elevated METT元 expression contributes to tumor aggression in GBC, suggesting that METT元 is a possible prognostic predictor and therapeutic target against GBC. Rescue assays showed that downregulation of DUSP5 could attenuate the knockdown METT元-mediated inhibition of cell proliferation, invasion, and migration of GBC-SD and NOZ cells. METT元 promoted the degradation of DUSP5 mRNA in a YTHDF2-dependent manner. Mechanistically, we revealed the METT元-mediated m 6A-modification profile in GBC cells and identified DUSP5 as the downstream gene of METT元. Functionally, we found that METT元 could promote cell proliferation, invasion, and migration of GBC-SD and NOZ cells. Here, we showed that upregulated METT元 level predicted poor prognosis and correlated with increased lymphatic metastasis and high TNM stage. However, dysregulation of METT元 in gallbladder cancer (GBC) remains obscure.
#AGE PROGRESSION NUDE SERIES#
N 6-methyladenosine (m 6A) RNA methylation and its associated methyltransferase METT元 play an important role in tumorigenesis of a series of tumors.
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